PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy)
PIPAC is a new and promising treatment method used in the tumors of ovaries, colon, stomach, and pancreas, which have spread to the peritoneum, and primary peritoneal tumors (mesothelioma, etc.). It can be implemented if HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and intravenous systemic chemotherapy cannot be administered. Its concomitant usage with the closed (laparoscopic) surgery is advantageous and the risk of side effects (pain and drug toxicity) is lower. A 1/10 of the dose, which is usually administered through the veins, is administered in aerosol form into the abdomen through a trocar (port) and then the drug in the aerosol form is drawn out with a special sponge system after the completion of the process through a second port. The pressurized application of the chemotherapeutic agents into the abdomen enables a homogeneous distribution of the drug and higher penetration in the cancer cells with a lower plasma concentration. Thus, the side effects are decreased. The short duration (30-60 minutes) and the repeatability (administration in 6-8 week intervals) of the procedure are other benefits of PIPAC.